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Sildenafil & Vardenafil
Silvitra

  • Sildenafil & Vardenafil Tablets
  • ED008
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per pill is $7.18 ! Buying from us will save you at least 40.81%

Package per pill Price SAVINGS BONUS Order
100/20mg * 30 pills
$4.25 $127.50 $0.00
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SILVER BONUS
for orders under $300
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100/20mg * 60 pills
$3.30 $198.00 $57.00
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SILVER BONUS
for orders under $300
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100/20mg * 90 pills
$2.70 $243.00 $139.50
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SILVER BONUS
for orders under $300
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►Next orders 10% discount
100/20mg * 120 pills
$2.25 $270.00 $240.00
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SILVER BONUS
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100/20mg * 180 pills
$1.99 $358.20 $406.80
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GOLD BONUS
for orders between $300 & $550
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100/20mg * 270 pills
$1.78 $480.60 $666.90
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GOLD BONUS
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►Free standard airmail service

Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium.

Vardenafil is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum.

Silvitra composition: Sildenafil Citrate 100mg and Vardenafil 20mg. It is advisable to divide the tablets into 2 or 4 parts, which was also stipulated by the manufacturer – there are convenient divisions on the tablets. Take the pill followed 30-40 minutes before sexual intercourse, and the effect lasts about 8-10 hours. It is worth remembering that alcohol and fatty foods reduce the effectiveness of the effect several times, as a result of which the time to erection increases. It should also be taken into account the fact that this medication contains the maximum recommended daily dose of sildenafil and vardenafil.

Erections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence. During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis.

Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.

Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Sildenafil appears to be completely metabolized in the liver to 16 metabolites. Its metabolism is mediated mainly by cytochrome P450 microsomal isozymes 3A4 (major route) and 2C9 (minor route). The major circulating metabolite, N-demethylated metabolite, has PDE selectivity similar to the parent drug and ~50% of its in vitro potency. The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite. Sildenafil also undergoes N-dealkylation followed by N-demethylation of the piperazine ring. / Vardenafil - is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms.

Absorption: Sildenafil - >90% absorbed with ~40% reaching systemic circulation unchanged following first-pass metabolism. / Vardenafil - is rapidly absorbed with absolute bioavailability of approximately 15%.

Route of elimination: Sildenafil: After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose). / Vardenafil: After oral administration, is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).

Half life: Sildenafil - 4 hours / Vardenafil - 4-5 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Sildenafil & Vardenafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common Sildenafil side effects may include: flushing (warmth, redness, or tingly feeling), headache, dizziness, heartburn, nausea, or upset stomach, abnormal vision (blurred vision, changes in color vision), runny or stuffy nose, nosebleeds, sleep problems (insomnia) or muscle pain, back pain.

Common Vardenafil side effects may include: flushing (warmth, redness, or tingly feeling), stuffy nose, sinus pain, headache, dizziness, upset stomach or back pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Nathan
17/Nov/2023

Silvitra helps me a lot with my erectile dysfunction problems. I have been taking it regularly for 5 month already and I am absolutely happy with this medication. It has no side effects; at least I haven't noticed any. While with other ED meds that I have tried before I experienced horrible complications at times, e.g. nausea, dizziness in the morning after taking a pill or blurred vision right after the sexual intercourse. All that is not really pleasant and that is why I was so glad when I found Silvitra that produces no such additional problems for me. But the main thing is that the medication is fairly effective in reducing my impotence symptoms like decrease in sexual vigor and stamina, unstable erection, problems with longevity and low interest in sex. Silvitra has the power of two highly popular erectile dysfunction meds - Viagra and Levitra - in one single pill. It increases the blood flow to the penis and in a matter of minutes my penis is hard and the erection lasts long. i can see real changes for the better as with Silvitra I can have a longer-lasting and more enjoyable experience. Besides I feel more confident of my masculinity. The medication has never let me down and I would recommend it to other people with the same problems.

Lance
15/Nov/2023

I am 29 years of age and I use Silvitra to increase my sexual performance on a regular basis. Actually I know that my disorder has psychological nature at the ground, but the funny trick is that only serious erectile dysfunction medication can help me solve these problems. It all started after one of my first sexual intercourses in my youth, when I was too drunk to have normal erection and the girl told all my college friends about that the next morning. That was horrible shame for me, all college students mocked at me and played dirty tricks for long months afterwards. Since that time I cannot have erection on my own, without any pills or medications. What is sad that quickly I develop addiction to such meds and in a month or two I have to look for another ED remedy. However with Silvitra everything is a bit different. It provides me with excellent sexual performance and helps me forget about my complex and problems. And I have been using it for more than 4 months mow and haven't noticed a single sign of addiction or decrease in Silvitra effectiveness. This medication provides me with everything I need and I strongly hope it will stay as effective as it is.

Adam
20/Oct/2023

At school and later at college I used to be a keen football player. I never dreamt about a career in football, but I was in the team and was quite successful. However once during the match I got badly kicked by another player when fighting for the ball. It was my unlucky day as his leg got into rough contact with my testicles and penis. I don't have to explain how painful it was, but what is still sadder is that afterwards I have had constant problems with my erection and even my sperm is not of the best quality. I haven't yet decided to have kids as I am yet 34 but I do hope there will not be too many problems when my time comes. However currently I face constant problems with sexual performance. My doctor told me that my erectile dysfunction is caused by the testicles trauma. Because of traumatized blood vessels the blood flow to the penis is insufficient and that is why I cannot always develop erection stable and long-lasting enough for a sexual intercourse. And in order to have normal sex I have to take some stimulating medications. I have chosen for me Silvitra, which is a combination of Viagra and Levitra and therefore I get the combined effect of the two excellent ED medications. Every time I am about to have sex with my girlfriend I take one pill of Silvitra and in less than 10 minutes I am all ready. My erection is strong and steady, besides I feel much more confident about my sexual power and abilities. This wonderful drug has never let me down and I am very satisfied with it.

Brian
12/Mar/2023

Not so long ago, actually about two years, I stepped into my 30's and since that time I am shocked to admit that I no longer have that sexual interest I used to have towards my opposite sex. I came to this sad conclusion after many tries and failures. I cannot even tell for sure how many girlfriends I have failed to have sex with during these two years; undoubtedly more than I have succeeded with. This is also the reason why I have no stable girlfriend. They need sex but I can't provide this on a regular basis. But please do not think that I have changed my preferences, men do not attract me at all. I love girls but I feel no more sexual excitement when I desperately need it. I did not know what I should do. I used to get awfully embarrassed when I couldn't achieve erection. I have read a lot on the internet about erectile dysfunction and medications used to treat it. I finally made my choice and ordered Silvitra. Good news started when the medication was delivered to my door next evening. It is really very convenient to order drugs from this website. Then I tried out the pills and was surprised as well - my erection was back and ready to help me have normal sex whenever I needed it.

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